|
KMID : 0861120080120020037
|
|
Korean Journal of Oriental Preventive Medicine
2008 Volume.12 No. 2 p.37 ~ p.49
|
|
|
The Effect to the Hepatic Metabolic Enzume that Uses Human Liver Microsome Caused by a Bariety of Yigiyak
|
|
Kim Hyun-Ho
Shin Yong-Cheol
Ko Seong-Gyu
|
|
|
Abstract
|
|
|
|
In this study, we experimented the influence of three herbal medicines, which are Saussurea lappa Clarke, Poncirus trifoliata Rafin, Citrus aurantium Linne, which are called ’Yigiyak(理氣藥)’ on drug metabolizing enzyme cytochrome P450 3A4 in Human Liver Microsome. Above all, the reason for this study is that herbal medicines can be assumed that herbs might have interactions with drugs, other herbs, alcohol and chemicals whether those are much better synergy effects than expected effects when the medicine was treated alone or not. As a result, we showed that all of five traditional herbal medicines had no CYP 3A4 inhibition effect on 10, 20, 30, 40, doses in Human Liver Microsome even Saussurea lappa Clarke showed a little inhibition as about 93% and 79% inhibition rate of control. However, this result are mostly not enough to prove that SLC has a CYP 3A4 inhibition effect. Moreover, it is not that those rates showed that those herbal medicines have CYP 3A4 induction effect. In conclusion, the result could support that those herbal medicines are more safe than chemical drugs even if this is the basic step to prove that result. Therefore, more specific studies to support this result, which are Kinetic study, cell and animal study then finally until clinical research, are required.
|
|
|
KEYWORD
|
|
|
hepatic metabolic enzume, Human liver microsome, Yigiyak, Traditional Korean medicine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|